by van Hemert, J and RA Baldock
Abstract:
The Edinburgh Mouse Atlas aims to capture in-situ gene expression patterns in a common spatial framework. In this study, we construct a grammar to define spatial regions by combinations of these patterns. Combinations are formed by applying operators to curated gene expression patterns from the atlas, thereby resembling gene interactions in a spatial context. The space of combinations is searched using an evolutionary algorithm with the objective of finding the best match to a given target pattern. We evaluate the method by testing its robustness and the statistical significance of the results it finds.
Reference:
Matching Spatial Regions with Combinations of Interacting Gene Expression Patterns (van Hemert, J and RA Baldock), In BioInformatics Research and Development (M Elloumi, \emphet al., eds.), Springer, volume 2, 2008.
Bibtex Entry:
@article{HB2008,
_day = {07},
abstract = {The Edinburgh Mouse Atlas aims to capture in-situ gene expression patterns in a common spatial framework. In this study, we construct a grammar to define spatial regions by combinations of these patterns. Combinations are formed by applying operators to curated gene expression patterns from the atlas, thereby resembling gene interactions in a spatial context. The space of combinations is searched using an evolutionary algorithm with the objective of finding the best match to a given target pattern. We evaluate the method by testing its robustness and the statistical significance of the results it finds.},
author = {van Hemert, J and RA Baldock},
date-added = {2008-08-18 12:44:11 +0100},
date-modified = {2008-08-18 12:44:11 +0100},
editor = {M Elloumi and \emph{et al.}},
journal = {BioInformatics Research and Development},
keywords = {data mining; biomedical; DGEMap; e-Science},
pages = {347--361},
publisher = {Springer},
series = {Communications in Computer and Information Science},
title = {Matching Spatial Regions with Combinations of Interacting Gene Expression Patterns},
volume = {2},
year = {2008},
bdsk-url-1 = {http://dx.doi.org/10.1007/978-3-540-71233-6_6}}