@article{Sadda2019a,
	abstract = {Purpose

To classify retinal nonperfusion regions (NPR) in patients with diabetic macular edema (DME) and assess the relationship with severity of DME.
Design

Prospective, observational case series.
Methods

Forty eyes of 29 patients with treatment-na{\"\i}ve center-involved macular edema secondary to diabetes mellitus were included (The DAVE study, NCT01552408) in this analysis. Ultra-widefield fluorescein angiography (UWF FA) images were transmitted to the Doheny Image Reading Center, where they were corrected using stereographic projection to adjust for peripheral distortion. Two independent, certified graders manually evaluated the NPR and classified the nonperfusion as being associated with leakage, or without leakage. The size of these two subtypes of NPR were computed in mm2 and assessed across the entire retina and within three concentric retinal zones. The relationship between subtype of NPR and the severity of DME was assessed.
Results

In forty eyes with treatment-na{\"\i}ve DME, visual acuity was significantly correlated with central macular thickness (CMT) and macular volume (MV). The NPR with leakage was positively correlated with CMT (R=0.408, P=0.009) and MV (R=0.399, P=0.011), whereas the NPR without leakage was negatively correlated with CMT (R=-0.468, P=0.002) and MV (R=-0.473, P=0.002). The NPR with leakage in the posterior region was significantly greater compared to the mid-periphery and the far-periphery (P<0.001), whereas the NPR without leakage was significantly greater in the mid-periphery compared to the far-periphery or the posterior region (P=0.001).
Conclusion

In patients with DME, the severity of DME appears to be positively correlated with NPR with leakage, but negatively correlated with NPR without leakage. These findings may have implications for the pathophysiology of DME and the design of protocols for targeted laser in these eyes.},
	annote = {doi: 10.1016/j.ajo.2019.03.030},
	author = {Fang, M and Fan, W and Shi, Y and Ip, MS and Wykoff, CC and Wang, K and Falavarjani, KG and Brown, DM and van Hemert, J and Sadda, SR},
	booktitle = {Am J Ophthalmol},
	date-added = {2019-04-18 21:24:00 +0100},
	date-modified = {2019-04-18 21:24:28 +0100},
	day = {18},
	doi = {10.1016/j.ajo.2019.03.030},
	isbn = {0002-9394},
	journal = {Am J Ophthalmol},
	keywords = {retinal imaging},
	publisher = {Elsevier},
	title = {Classification of Regions of Nonperfusion on Ultra-widefield Fluorescein Angiography in patients with Diabetic Macular Edema},
	url = {https://doi.org/10.1016/j.ajo.2019.03.030},
	year = {2019},
	bdsk-url-1 = {https://doi.org/10.1016/j.ajo.2019.03.030}}