@article{Fan2020-zb, abstract = {AIM: To evaluate the fractal feature of the retinal vasculature of normal eyes on a stereographic projected and montaged ultra-wide field (UWF) fluorescein angiography (FA). METHODS: Prospective, observational, cross-sectional study. Totally 59 eyes of 31 normal subjects were imaged using the Optos 200Tx. Images obtained at different gaze angles stereographically projected and montaged. The early-phase UWF FA frames were processed to segment the retinal vasculature and the results were exported as binary masks. The fractal dimension (FD) was calculated using the box-counting method. RESULTS: The global FD for the entire retina was 1.6$\pm$0.04, with no difference between males and females (1.59$\pm$0.04 vs 1.61$\pm$0.04, P=0.084) or between right and left eyes (1.6$\pm$0.04 vs 1.6$\pm$0.05, P=0.61). FD was non-uniformly distributed among four quadrants (P0.05). CONCLUSION: Fractal geometry is non-uniformly distributed across the retina in normal eyes and decreases from the fovea to the far-periphery. Subjects with an older age tend to have a smaller FD, however, the FD in the far-periphery does not appear to be influenced by age.}, author = {Fan, W-Y and Fleming, A and Robertson, G and Uji, A and van Hemert, J and Singer, M and Sagong, M and Ip, M and Sadda, SR}, date-added = {2024-01-05 15:33:05 +0000}, date-modified = {2024-01-05 15:35:41 +0000}, journal = {Int. J. Ophthalmol.}, keywords = {retinal imaging}, number = 7, pages = {1109--1114}, title = {Fractal analysis of retinal vasculature in normal subjects on ultra-wide field fluorescein angiography}, volume = 13, year = 2020}