@article{Fan2023-wg,
	abstract = {PURPOSE: To determine the relationship between baseline retinal
               non-perfusion area (NPA) and retinal vascular bed area (RVBA) on
               ultra-wide field fluorescein angiography (UWF FA) and long-term
               response to intravitreal ranibizumab therapy in diabetic macular
               oedema (DMO). METHODS: A post-hoc, 2-year observational case
               series. Baseline UWF FA images (Optos 200Tx) of 40 eyes from 29
               patients with diabetes mellitus and treatment na{\"\i}ve DMO in
               the DAVE (NCT01552408) study were montaged and stereographically
               projected at the Doheny Image Reading Center to adjust for
               peripheral distortion. The retinal vasculature was automatically
               extracted to calculate RVBA. NPA was manually delineated by two
               masked certified graders. RVBA and NPA were computed in mm2
               automatically by adjusting for peripheral distortion and then
               correlated with the severity of DMO. RESULTS: While global NPA
               at baseline was not correlated to retinal thickness
               measurements, baseline NPA in the superior retina was associated
               with the macular volume (MV) improvement (P = 0.022).
               Multivariate analysis revealed a smaller RVBA at baseline was
               correlated with a better MV outcome at two-year follow-up after
               adjusting for confounding factors (P = 0.049). CONCLUSION: Eyes
               with smaller baseline RVBA appear to have a better long-term
               anatomic outcome of DMO.},
	author = {Fan, W and Uji, A and Wykoff, CC and Brown, DM and van Hemert, J and Falavarjani, KG and Wang, K and Sadda, SR and Ip, M},
	date-added = {2024-01-05 15:33:05 +0000},
	date-modified = {2024-01-05 15:35:33 +0000},
	journal = {Eye},
	keywords = {retinal imaging},
	number = 4,
	pages = {678--683},
	title = {Baseline retinal vascular bed area on ultra-wide field fluorescein angiography correlates with the anatomical outcome of diabetic macular oedema to ranibizumab therapy: two-year analysis of the {DAVE} Study},
	volume = 37,
	year = 2023}