Association between hypertension and retinal vascular features in ultra-widefield fundus imaging (bibtex)
	abstract = {Objective  Changes to the retinal vasculature are known to be associated with hypertension independently of traditional risk factors. We investigated whether measurements of retinal vascular calibre from ultra-- To cite: Robertson G, Fleming A, widefield fundus imaging were associated with Williams MC, et al. Association hypertensive status. between hypertension and
Methods  We retrospectively collected and retinal vascular features in ultra-- semiautomatically measured ultra--widefield retinal widefield fundus imaging. Open fundus images from a subset of participants enrolled in Heart 2020;7:e001124. doi:10.1136/ openhrt-2019-001124 an ongoing population study of ageing, categorised as normotensive or hypertensive according to thresholds on systolic/diastolic blood pressure (140/90 mm Hg) measured in a clinical setting. Vascular calibre in the Received 27 June 2019 Revised 27 November 2019 peripheral retina was measured to calculate the nasal--annular arteriole:venule ratio (NA--AVR), a novel combined Accepted 17 December 2019 parameter.
Results  Left and right eyes were analysed from 440 participants (aged 50--59 years, mean age of 54.6$\pm$2.9 years, 247, 56.1\% women), including 151 (34.3\%) categorised as hypertensive. Arterioles were thinner and the NA-A- VR was smaller in people with hypertension. The area under the receiver operating characteristic curve of NA--AVR for hypertensive status was 0.73 (95\% CI 0.68 to 0.78) using measurements from left eyes, while for right eyes, it was 0.64 (95\% CI 0.59 to 0.70), representing evidence of a statistically significant difference between the eyes (p=0.020).
Conclusions  Semiautomated measurements of NA--AVR in ultra-w- idefield fundus imaging were associated with hypertension. With further development, this may help screen people attending routine eye health check--ups for high blood pressure. These individuals may then follow a care pathway for suspected hypertension. Our results showed differences between left and right eyes, highlighting the importance of investigating both eyes of {\copyright} Author(s) (or their},
	author = {Robertson, G. and Fleming, A. and Williams, M.C. and Trucco, E. and Quinn, N. and Hogg, R. and McKay, G.J. and Kee, F. and Young, I. and Pellegrini, E. and Newby, D.E. and van Beek, E.J.R. and Peto, T. and Dhillon, B. and van Hemert, J. and MacGillivray, T.J.},
	copyright = {Creative Commons Attribution-ShareAlike 4.0 International License (CC-BY-SA)},
	date-added = {2020-10-07 14:43:14 +0100},
	date-modified = {2020-10-07 14:44:11 +0100},
	doi = {10.1136/openhrt-2019-001124},
	file = {Robertson et al. - 2020 - Association between hypertension and retinal vascu.pdf:/Users/jvhemert/Dropbox (Personal)/Apps/Zotero/storage/HGCRUIBX/Robertson et al. - 2020 - Association between hypertension and retinal vascu.pdf:application/pdf},
	issn = {2053-3624},
	journal = {Open Heart},
	keywords = {retinal imaging},
	language = {en},
	month = jan,
	number = {1},
	pages = {e001124},
	title = {Association between hypertension and retinal vascular features in ultra-widefield fundus imaging},
	url = {},
	urldate = {2020-04-03},
	volume = {7},
	year = {2020},
	bdsk-url-1 = {},
	bdsk-url-2 = {}}
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