@article{robertson_association_2020,
	abstract = {Objective  Changes to the retinal vasculature are known to be associated with hypertension independently of traditional risk factors. We investigated whether measurements of retinal vascular calibre from ultra-- To cite: Robertson G, Fleming A, widefield fundus imaging were associated with Williams MC, et al. Association hypertensive status. between hypertension and
Methods  We retrospectively collected and retinal vascular features in ultra-- semiautomatically measured ultra--widefield retinal widefield fundus imaging. Open fundus images from a subset of participants enrolled in Heart 2020;7:e001124. doi:10.1136/ openhrt-2019-001124 an ongoing population study of ageing, categorised as normotensive or hypertensive according to thresholds on systolic/diastolic blood pressure (140/90 mm Hg) measured in a clinical setting. Vascular calibre in the Received 27 June 2019 Revised 27 November 2019 peripheral retina was measured to calculate the nasal--annular arteriole:venule ratio (NA--AVR), a novel combined Accepted 17 December 2019 parameter.
Results  Left and right eyes were analysed from 440 participants (aged 50--59 years, mean age of 54.6$\pm$2.9 years, 247, 56.1\% women), including 151 (34.3\%) categorised as hypertensive. Arterioles were thinner and the NA-A- VR was smaller in people with hypertension. The area under the receiver operating characteristic curve of NA--AVR for hypertensive status was 0.73 (95\% CI 0.68 to 0.78) using measurements from left eyes, while for right eyes, it was 0.64 (95\% CI 0.59 to 0.70), representing evidence of a statistically significant difference between the eyes (p=0.020).
Conclusions  Semiautomated measurements of NA--AVR in ultra-w- idefield fundus imaging were associated with hypertension. With further development, this may help screen people attending routine eye health check--ups for high blood pressure. These individuals may then follow a care pathway for suspected hypertension. Our results showed differences between left and right eyes, highlighting the importance of investigating both eyes of {\copyright} Author(s) (or their},
	author = {Robertson, G and Fleming, A and Williams, MC and Trucco, E and Quinn, N and Hogg, R and McKay, GJ and Kee, F and Young, I and Pellegrini, E and Newby, DE and van Beek, EJR and Peto, T and Dhillon, B and van Hemert, J and MacGillivray, TJ},
	copyright = {Creative Commons Attribution-ShareAlike 4.0 International License (CC-BY-SA)},
	date-added = {2020-10-07 14:38:42 +0100},
	date-modified = {2024-01-05 15:42:22 +0000},
	doi = {10.1136/openhrt-2019-001124},
	file = {Robertson et al. - 2020 - Association between hypertension and retinal vascu.pdf:/Users/jvhemert/Dropbox (Personal)/Apps/Zotero/storage/HGCRUIBX/Robertson et al. - 2020 - Association between hypertension and retinal vascu.pdf:application/pdf},
	issn = {2053-3624},
	journal = {Open Heart},
	keywords = {retinal imaging},
	language = {en},
	number = {1},
	pages = {e001124},
	title = {Association between hypertension and retinal vascular features in ultra-widefield fundus imaging},
	url = {http://openheart.bmj.com/lookup/doi/10.1136/openhrt-2019-001124},
	urldate = {2020-04-03},
	volume = {7},
	year = {2020},
	bdsk-url-1 = {http://openheart.bmj.com/lookup/doi/10.1136/openhrt-2019-001124},
	bdsk-url-2 = {https://doi.org/10.1136/openhrt-2019-001124}}